Kwan-Kyu Park Selected Research

Apamin

1/2021	Apamin inhibits renal fibrosis via suppressing TGF-β1 and STAT3 signaling in vivo and in vitro.
12/2020	Antioxidative, Antiapoptotic, and Anti-Inflammatory Effects of Apamin in a Murine Model of Lipopolysaccharide-Induced Acute Kidney Injury.
1/2020	Therapeutic Effects of Apamin as a Bee Venom Component for Non-Neoplastic Disease.
10/2017	The Effects of Melittin and Apamin on Airborne Fungi-Induced Chemical Mediator and Extracellular Matrix Production from Nasal Polyp Fibroblasts.
5/2017	Apamin suppresses biliary fibrosis and activation of hepatic stellate cells.
7/2015	Apamin inhibits PDGF-BB-induced vascular smooth muscle cell proliferation and migration through suppressions of activated Akt and Erk signaling pathway.
4/2015	Melittin has a chondroprotective effect by inhibiting MMP-1 and MMP-8 expressions via blocking NF-κB and AP-1 signaling pathway in chondrocytes.
6/2014	Melittin suppresses EGF-induced cell motility and invasion by inhibiting PI3K/Akt/mTOR signaling pathway in breast cancer cells.
8/2012	Apamin inhibits THP-1-derived macrophage apoptosis via mitochondria-related apoptotic pathway.
1/2012	The Protective Effect of Apamin on LPS/Fat-Induced Atherosclerotic Mice.

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Kwan-Kyu Park Research Topics

Disease

32	Fibrosis (Cirrhosis) 01/2024 - 05/2006
30	Inflammation (Inflammations) 01/2024 - 02/2004
23	Neoplasms (Cancer) 09/2021 - 10/2003
13	Atherosclerosis 05/2023 - 01/2010
12	Liver Cirrhosis (Hepatic Cirrhosis) 01/2024 - 05/2006
9	Ureteral Obstruction 07/2022 - 08/2006
9	Neoplasm Metastasis (Metastasis) 01/2021 - 07/2005
8	Pain (Aches) 01/2017 - 03/2007
7	Liver Diseases (Liver Disease) 01/2024 - 02/2010
6	Atopic Dermatitis (Atopic Eczema) 12/2023 - 01/2013
6	Hypoxia (Hypoxemia) 12/2023 - 03/2011
6	Acute Kidney Injury (Acute Renal Failure) 09/2021 - 08/2019
5	Skin Diseases (Skin Disease) 12/2018 - 07/2014
5	Rheumatoid Arthritis 01/2017 - 05/2009
5	Arthritis (Polyarthritis) 11/2015 - 12/2008
4	Acne Vulgaris 12/2022 - 11/2014
4	Osteosarcoma (Osteogenic Sarcoma) 09/2017 - 10/2006
4	Carcinoma (Carcinomatosis) 01/2015 - 04/2012
2	Liver Neoplasms (Liver Cancer) 01/2024 - 04/2016
2	Wounds and Injuries (Trauma) 05/2023 - 07/2009
2	Chronic Renal Insufficiency 03/2021 - 08/2016
2	Renal Cell Carcinoma (Grawitz Tumor) 04/2020 - 07/2005
2	Hyperlipidemias (Hyperlipidemia) 01/2020 - 10/2006
2	Lung Neoplasms (Lung Cancer) 01/2019 - 02/2017
2	Periodontitis 02/2018 - 11/2016
2	Nasal Polyps (Nasal Polyp) 10/2017 - 01/2013
2	Glioma (Gliomas) 12/2015 - 05/2009
2	Rheumatic Diseases (Rheumatism) 04/2015 - 01/2013
2	Adenocarcinoma of Lung 01/2015 - 01/2014
2	Breast Neoplasms (Breast Cancer) 06/2014 - 02/2010
2	Necrosis 12/2010 - 01/2010
2	Chronic Disease (Chronic Diseases) 07/2010 - 01/2010
2	Diabetic Nephropathies (Diabetic Nephropathy) 02/2008 - 06/2006
2	Hyperglycemia 10/2006 - 01/2005
1	Infections 09/2022
1	Colorectal Neoplasms (Colorectal Cancer) 01/2021
1	Atrophy 01/2021
1	Renal Insufficiency (Renal Failure) 01/2021

Drug/Important Bio-Agent (IBA)

26	Bee Venoms (Bee Venom)IBA 09/2022 - 12/2008
22	Melitten (Melittin)IBA 09/2022 - 02/2010
16	OligodeoxyribonucleotidesIBA 01/2024 - 10/2003
15	CytokinesIBA 01/2024 - 03/2007
12	Transcription Factors (Transcription Factor)IBA 05/2023 - 02/2008
11	ApaminIBA 01/2021 - 02/2010
10	Proteins (Proteins, Gene)FDA Link 01/2024 - 05/2006
7	LipopolysaccharidesIBA 12/2020 - 01/2010
6	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 09/2022 - 02/2010
6	Therapeutic UsesIBA 09/2022 - 06/2015
6	Transforming Growth Factors (Transforming Growth Factor)IBA 09/2018 - 05/2006
5	Fibronectins (Fibronectin)IBA 09/2022 - 12/2010
5	Cisplatin (Platino)FDA LinkGeneric 09/2021 - 01/2018
5	ascochlorinIBA 01/2018 - 07/2005
4	Epidermal Growth Factor (EGF)IBA 01/2019 - 04/2012
4	Peptides (Polypeptides)IBA 05/2017 - 02/2010
4	NF-kappa B (NF-kB)IBA 04/2015 - 04/2009
4	Cadherins (E-Cadherin)IBA 01/2015 - 01/2013
4	Transforming Growth Factor beta1 (TGF beta 1)IBA 09/2009 - 05/2006
3	InterleukinsIBA 09/2022 - 12/2010
3	Carbon Tetrachloride (Tetrachloromethane)IBA 08/2018 - 09/2009
3	Anti-Bacterial Agents (Antibiotics)IBA 01/2018 - 06/2009
3	Matrix Metalloproteinases (MMPs)IBA 09/2017 - 07/2005
3	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 02/2017 - 04/2012
3	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 08/2016 - 04/2012
3	CholesterolIBA 04/2013 - 10/2006
2	Beclin-1IBA 07/2022 - 03/2021
2	OligonucleotidesIBA 07/2022 - 03/2021
2	STAT3 Transcription Factor (Signal Transducer and Activator of Transcription 3)IBA 03/2021 - 09/2018
2	Biomarkers (Surrogate Marker)IBA 04/2020 - 08/2015
2	Fatty Acids (Saturated Fatty Acids)IBA 01/2020 - 10/2006
2	Hormones (Hormone)IBA 01/2020 - 11/2019
2	MelatoninIBA 01/2020 - 11/2019
2	Immunoglobulin E (IgE)IBA 12/2017 - 12/2016
2	AllergensIBA 12/2017 - 12/2016
2	IsothiocyanatesIBA 09/2017 - 12/2015
2	phenethyl isothiocyanate (PEITC)IBA 09/2017 - 12/2015
2	Transcription Factor AP-1 (Transcription Factor AP 1)IBA 09/2017 - 04/2015
2	CateninsIBA 04/2016 - 01/2013
2	Collagen Type II (Type II Collagen)IBA 04/2015 - 12/2008
2	Plasminogen Activator Inhibitor 1IBA 01/2015 - 01/2014
2	Collagen Type I (Type I Collagen)IBA 01/2014 - 08/2006
2	70-kDa Ribosomal Protein S6 Kinases (Ribosomal Protein S6 Kinases, 70 kDa)IBA 01/2013 - 04/2012
2	Cell Adhesion MoleculesIBA 01/2012 - 12/2010
2	Ethanol (Ethyl Alcohol)IBA 07/2010 - 01/2010
2	Matrix Metalloproteinase 9 (Gelatinase B)IBA 02/2010 - 07/2005
2	Cyclooxygenase 2 (Cyclooxygenase-2)IBA 03/2007 - 02/2004
1	STAT5 Transcription FactorIBA 12/2023
1	Peroxisome Proliferator-Activated Receptors (PPAR)IBA 12/2022
1	Untranslated RNA (Noncoding RNA)IBA 09/2022
1	Microtubule-Associated Proteins (Microtubule-Associated Protein 2)IBA 07/2022
1	shogaolIBA 09/2021
1	Epithelial Cell Adhesion MoleculeIBA 01/2021
1	Leukocyte Common Antigens (CD45 Antigen)IBA 01/2021
1	garcinolIBA 12/2020
1	Histones (Histone)IBA 12/2020
1	kahweolIBA 12/2020
1	EndotoxinsIBA 12/2020

Therapy/Procedure

12	Therapeutics 01/2024 - 10/2014
3	East Asian Traditional Medicine (Oriental Medicine) 01/2018 - 02/2010
1	Intraperitoneal Injections 05/2023
1	Neoadjuvant Therapy 01/2021